Nucleic acid-containing nanoparticles
Disclosed herein are nanoparticles comprising phospholipids, apolipoproteins and/or apolipoprotein mimetics, sterols, cationic lipids or ionizable cationic lipids, and nucleic acids, as well as compositions comprising such nanoparticles and methods for preparing such nanoparticles. The nanoparticles...
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| Main Authors | , , , , , , , |
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| Format | Patent |
| Language | Chinese English |
| Published |
09.02.2024
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Disclosed herein are nanoparticles comprising phospholipids, apolipoproteins and/or apolipoprotein mimetics, sterols, cationic lipids or ionizable cationic lipids, and nucleic acids, as well as compositions comprising such nanoparticles and methods for preparing such nanoparticles. The nanoparticles can be used as medicaments, for example, to treat diseases by stimulating or inhibiting innate immune responses.
本文公开了包含磷脂、载脂蛋白和/或载脂蛋白模拟物、甾醇、阳离子脂质或可电离的阳离子脂质和核酸的纳米颗粒，以及包含此类纳米颗粒的组合物和用于制备此类纳米颗粒的方法。纳米颗粒可以用作药物，例如通过刺激或抑制先天免疫应答来治疗疾病。 |
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| AbstractList | Disclosed herein are nanoparticles comprising phospholipids, apolipoproteins and/or apolipoprotein mimetics, sterols, cationic lipids or ionizable cationic lipids, and nucleic acids, as well as compositions comprising such nanoparticles and methods for preparing such nanoparticles. The nanoparticles can be used as medicaments, for example, to treat diseases by stimulating or inhibiting innate immune responses.
本文公开了包含磷脂、载脂蛋白和/或载脂蛋白模拟物、甾醇、阳离子脂质或可电离的阳离子脂质和核酸的纳米颗粒，以及包含此类纳米颗粒的组合物和用于制备此类纳米颗粒的方法。纳米颗粒可以用作药物，例如通过刺激或抑制先天免疫应答来治疗疾病。 |
| Author | P.M.FRANSON MULDER WILHELMUS JOHANNES MARIA ZWOLSMAN REBECCA C HOFSTRAAT, STEFAN VAN DER MEER ROELOF KLUZAR ERHARD AMBERGEN TOBIAS JENSEN HELENE MARIE |
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| DocumentTitleAlternate | 含有核酸的纳米颗粒 |
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| Snippet | Disclosed herein are nanoparticles comprising phospholipids, apolipoproteins and/or apolipoprotein mimetics, sterols, cationic lipids or ionizable cationic... |
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| Title | Nucleic acid-containing nanoparticles |
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