Pyridazinone derivative containing quaternary phosphonium salt structure as well as preparation method and application of pyridazinone derivative

• Main Authors: LIN YU, CUI HANGRUI, ZHANG RUIFENG, WANG TING, MIN ZHENLI
• Format: Patent
• Language: Chinese; English
• Published: 02.01.2024
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a pyridazinone derivative containing a quaternary phosphonium salt structure and a preparation method and application thereof.The pyridazinone derivative has the structure shown in the formula (I), and the preparation method comprises the specific steps that 1, a compound shown in the formula (II) is added into dichloromethane, stirring is conducted to form a suspension, DIPEA is dropwise added, HATU is added under the ice bath condition, stirring is conducted for a reaction, and a compound shown in the formula (II) is obtained; adding 4-hydroxypiperidine into the reaction liquid, removing the ice bath, stirring at room temperature, and carrying out silica gel column chromatography separation to obtain a compound as shown in a formula (III); (2) respectively carrying out esterification reaction on the compound as shown in the formula (III) and 3-bromopropionyl chloride, 4-bromobutyryl chloride, 5-bromovaleryl chloride and 6-bromohexanoyl chloride to obtain a compound as shown in a form