Application of SC-43 in preparation of gram-positive bacterial infection resisting medicine

• Main Authors: PENG RENHAI, LAN QIQI, HUANG JINLIAN, LI PEIYU, LI WEIFEN, HE PEIKUN, YU ZHIJIAN
• Format: Patent
• Language: Chinese; English
• Published: 08.12.2023
• Subjects: ADHESIVES; AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMICAL PAINT OR INK REMOVERS; CHEMISTRY; COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS; CORRECTING FLUIDS; DYES; FILLING PASTES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INKS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; PAINTS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING; USE OF MATERIALS THEREFOR; WOODSTAINS

The invention provides an application of SC-43 in preparation of a medicine for resisting gram-positive bacterial infection, and the CAS number of the SC-43 is 1400989-25-4; the SC-43 has the effect of inhibiting the growth of gram-positive bacteria and the formation of a biofilm. According to the technical scheme, the novel medical application of the SC-43 is disclosed, and the SC-43 shows better antibacterial activity on various gram-positive bacteria and can remarkably inhibit formation of a biofilm; the antibacterial activity can be comparable with that of Van (vancomycin), and is superior to that of Van, and the biological activity of efficiently killing staphylococcus aureus is reflected; and the SC-43 can influence the permeability of the membrane. 本发明提供了SC-43用于制备抗革兰氏阳性细菌感染药物中的应用，所述SC-43，CAS编号为1400989-25-4；所述SC-43具有抑制革兰氏阳性细菌的生长和生物被膜形成的作用。本发明的技术方案公开了SC-43的医药新用途，SC-43对多种革兰氏阳性细菌表现出较佳的抗菌活性，能够显著抑制生物被膜的形成；具有可与Van(万古霉素)媲美的抑菌活性，且优于Van的杀菌活性，且体现出高效杀灭金黄色葡萄球菌的生物学活性；SC-43可影响膜的通透性。