New application of NU6300

• Main Authors: WU WENSHUANG, YE HAOYU, JIANG XUEQIN
• Format: Patent
• Language: Chinese; English
• Published: 03.11.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides novel application of NU6300, and belongs to the technical field of medicine. The invention provides a new application of NU6300 in inhibition of pyroptosis. The invention verifies that the NU6300 has a treatment effect on colitis by inhibiting pyroptosis and remarkably reducing DSS-induced epithelium and mucous membrane lesions, crypt dilation and goblet cell depletion, and verifies that the NU6300 has a protection effect on LPS-induced sepsis by inhibiting pyroptosis, and the protection effect of the NU6300 on the LPS-induced sepsis is superior to that of NAS. It is proved that NU6300 can play an important role in drugs for treating pyroptosis-mediated diseases and has good clinical application value. 本发明提供了一种NU6300的新用途，属于医学技术领域。本发明提供了NU6300抑制细胞焦亡的新用途。并且本发明验证了NU6300通过抑制细胞焦亡，显著减轻DSS诱导的上皮和黏膜损伤、隐窝扩张和杯状细胞耗竭对结肠炎有治疗作用，以及验证了NU6300通过抑制细胞焦亡，对LPS诱导的脓毒症的保护作用，且NU6300对LPS诱导的脓毒症的保护作用优于NAS。证实NU6300可以在细胞焦亡介导的疾病治疗药物中起到重要作用，具有很好的临床应用价值。