Composition for preventing or treating brain function decline or maintaining or improving brain function

• Main Authors: KAWAHARA TOMOHIRO, UEDA ATSUSHI, YAMADA TAKUJI, USHIDA KAZUNARI, TSUCHIDA, SAYAKA, KOUDA NORIYUKI, KITAMURA AKIHIKO, KOBAYASHI YOUDAI, SHINKAI SHOJI, KARIYA TAKAHIRO
• Format: Patent
• Language: Chinese; English
• Published: 22.09.2023
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention addresses the problem of providing a method for evaluating dementia and a composition for preventing or treating a decrease in brain function or maintaining or improving brain function, and comparing intestinal microbiota in healthy persons, mild cognitive impairment persons, and Alzheimer's disease patients. As a result, a microorganism belonging to the genus Fecalis, or the like, which is an enteral microorganism associated with cognitive function, is screened out. Further, it has been clarified that the F. przewalskii having a specific DNA has an improvement effect on a decrease in brain function such as learning/memory disorders. 课题在于，提供痴呆症的评价方法及用于预防或治疗脑功能下降或者维持或改善脑功能的组合物，对健康者、轻度认知障碍者、及阿尔茨海默病患者的肠内微生物群进行比较。其结果是，筛选出作为与认知功能有关联的肠内微生物的、属于粪杆菌属的微生物等。进而，明确了具有特定DNA的普氏栖粪杆菌对学习/记忆障碍等脑功能下降发挥改善效果。