Salts and crystals

• Main Authors: REICH, THOMAS, LAWRENCE R MICHAEL, ALSOP HERVE
• Format: Patent
• Language: Chinese; English
• Published: 12.09.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to solid forms of 1-methyl-1, 4, 5, 10-tetrahydropyrazolo [3, 4-b] [1, 5] benzodiazepine free base having desirable pharmacokinetic properties, such as low hygroscopicity and improved thermal stability. These solid forms include crystalline forms of the 1-methyl-1, 4, 5...