Application of loofah sponge extract in preparation of medicine for inducing cell autophagy and treating Alzheimer disease

• Main Authors: LONG TAO, CHEN XUE, ZHOU XIAOGANG, WU JIANMING, YU LU, WU ANGUO, QIN DALIAN
• Format: Patent
• Language: Chinese; English
• Published: 05.09.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of a loofah sponge extract in preparation of a medicine for inducing cell autophagy and treating Alzheimer's disease, and belongs to the technical field of biomedicine. The loofah sponge extract is an ethanol extract of vascular bundles of air-dried loofah fruits. The loofah sponge extract obtained by the invention can inhibit A beta deposition, relieve A beta and Tau pathology of caenorhabditis elegans, and induce cell autophagy to inhibit oxidative stress and toxicity induced by the cell autophagy, thereby achieving the purpose of treating and relieving Alzheimer's disease. 本发明公开了一种丝瓜络提取物在制备诱导细胞自噬及治疗阿尔茨海默病药物中的用途，属于生物医疗技术领域。本申请中的丝瓜络提取物为风干后的丝瓜果实的维管束的乙醇提取物。本发明获得了丝瓜络提取物，其能够抑制Aβ沉积，减轻秀丽隐杆线虫的Aβ和Tau病理，还可诱导细胞自噬来抑制其诱导的氧化应激和毒性，从而达到治疗、缓解阿尔茨海默病的目的。