Layered method for assessing progression and risk of advanced colorectal adenoma and colorectal cancer

• Main Authors: HERRING ERIC, TREMBLAY ERIC, BEAULIEU JEAN-FRANCOIS
• Format: Patent
• Language: Chinese; English
• Published: 22.08.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present disclosure relates to a method of stratifying the risk of a subject having advanced colorectal adenoma or colorectal cancer based on determining the presence of an overexpressed mRNA transcript in the feces of the subject. The methods can be used to screen subjects suitable for colonoscopy. The method may also be used to customize the treatment regimen of the stratified subject. 本公开涉及基于确定受试者粪便中过表达的mRNA转录本的存在来分层受试者患有晚期结直肠腺瘤或结直肠癌的风险的方法。该方法可用于筛查适于结肠镜的受试者。该方法还可用于定制被分层的受试者的治疗方案。