Method for simulating conversion of ginsenoside Rg3 into PPD in intestinal tract

• Main Author: REN HONGCAN
• Format: Patent
• Language: Chinese; English
• Published: 22.08.2023
• Subjects: CALCULATING; COMPUTING; COUNTING; ELECTRIC DIGITAL DATA PROCESSING; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

The invention discloses a method for simulating conversion of ginsenoside Rg3 into PPD in intestinal tracts, and mainly relates to the technical field of computational pharmacokinetics. Comprising the following steps: S1, measuring a rate constant that ginsenoside Rg3 is converted into a metabolite (PPD) in an intestinal tract; s2, measuring the pharmacokinetic data of the ginsenoside Rg3 metabolite (PPD); s3, compiling a series of differential equations, inputting parameters, and establishing a transformation model of ginsenoside Rg3 in vivo; s4, inputting Dose, k12, k10, ka, k38, k83, k30 and kt into the ginsenoside Rg3 deglycosylation kinetic model in S3, so as to obtain a PK curve of the metabolite of the medicine; the deglycosylation kinetic model is established for the first time, and the whole process that drugs are metabolized into metabolites through intestinal flora and then absorbed into blood can be simulated. 本发明公开了一种模拟人参皂苷Rg3在肠道内转化为PPD的方法，主要涉及计算药代动力学技术领域；包括步骤：S1、测得人参皂苷Rg3在肠道内转化为代谢物(PPD)的速率常数；S2、