Immune checkpoint inhibitors conjugated to ultrasonic sensitizers and uses thereof

• Main Authors: JUNG EUN-AH, KIM HYUN-RYUNG, KIM YOON-SUK, KIM DAE-HYUN
• Format: Patent
• Language: Chinese; English
• Published: 04.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to an immune checkpoint inhibitor conjugated with an ultrasonic sensitive agent, application of the immune checkpoint inhibitor and the like. The immune checkpoint inhibitor conjugate conjugated with an ultrasonic sensitive agent according to the present invention has tumor selectivity with respect to targeted therapy, and specifically responds to ultrasonic waves, and thus can be used to produce a drug for diagnosing and treating cancer. In particular, the conjugate of the present invention exhibits excellent solubility and stability in an aqueous solution, and provides an excellent anti-cancer effect compared to a simple immune checkpoint inhibitor, and thus is expected to be useful as a novel drug for the treatment of cancer. 本发明涉及一种与超声波敏感剂缀合的免疫检查点抑制剂、其用途等。根据本发明的与超声波敏感剂缀合的免疫检查点抑制剂缀合物具有关于靶向治疗的肿瘤选择性，并且特异性地响应于超声波，并且因此可以用来生产用于诊断和治疗癌症的药物。特别地，本发明的缀合物在水溶液中表现出优异的溶解性和稳定性，并且与单纯的免疫检查点抑制剂相比提供优异的抗癌效果，并且因此被预期可用作用于治疗癌症的新型药物。