Alkanoic acid ester compound as well as preparation method and application thereof

• Main Authors: YANG JIAXI, XIAO XIAOWU, LIN KAIPENG, WANG JIE, ZHOU ZHIQIANG, WU MINYU, FU HUIZHENG
• Format: Patent
• Language: Chinese; English
• Published: 27.06.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of traditional Chinese medicine extraction and separation, phytochemistry and medicine, in particular to an alkanoate compound and a preparation method and application thereof. The invention provides a novel compound extracted from rhizoma typhonii flagelliformis. Dry rhizoma typhonii flagelliformis is used as a raw material, and the novel alkanoate compound is obtained through the steps of adding water to decoct, concentrating under reduced pressure, extracting, performing reversed-phase C18 chromatographic separation and the like. The extraction and separation process is simple to operate, easy to control and suitable for industrial production; the obtained alkanoate compound has anti-proliferative activity and an anti-tumor effect, and has a good application prospect in preparation of drugs for treating non-small cell lung cancer. 本发明涉及中药提取分离、植物化学及医药技术领域，具体涉及一种烷酸酯化合物及其制备方法与应用。本发明提供了从水半夏中提取的一种新化合物：以干燥的水半夏为原料，通过加水煎煮、减压浓缩、萃取、反相C18色谱分离等步骤得到一种新的烷酸酯化合物。本发明提取分离工艺操作简单、易