Preparation of Emectin G and application of Emectin G in drug research and development

• Main Authors: XIE ZEPING, GAO XIAOSHA, DAI SHENGJUN, ZHAO MING, GONG SHIZHOU, QU CHENGLEI, SHEN SHENGBIAO, ZHANG SHUMIN
• Format: Patent
• Language: Chinese; English
• Published: 25.04.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to a chemical structure and a preparation method of a novel compound Emecin G, and application of the novel compound Emecin G in research and development of novel antibacterial drugs. Emectin G is a novel compound found from secondary metabolites of marine actinomycetes Streptomyces sp.strain KCB-032 by the applicant of the invention, and the pharmacological activity research finds that the compound has a relatively good growth inhibition effect on two bacteria. The chemical structure, the preparation method and the antibacterial pharmacological activity of the Emcin G are disclosed for the first time, and the Emcin G has the potential of being researched and developed into a novel antibacterial drug. 本发明涉及新化合物Emycin G的化学结构、制备方法，以及在抗菌新药研发中的应用。Emycin G是本发明申请人从海洋放线菌Streptomyces sp.strain KCB-032的次生代谢产物中发现的新化合物，药理活性研究发现，该化合物对2种细菌具有较好的生长抑制作用。Emycin G的化学结构、制备方法及其抗菌药理活性均为首次公开，具有研发成为新型抗菌药物的潜力。