Methods of genetically modifying cells for delivery of therapeutic proteins

• Main Authors: DUCHATEAU, PHILIPPE, JUILLERAT ALEXANDRE, BUSSER BRIAN, POIROT LAURENT, HUNG PATRICK, BOYEN ALEX
• Format: Patent
• Language: Chinese; English
• Published: 24.02.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present disclosure provides methods of genetically modifying a cell by insertion of an artificial exon (ArtEx) for delivery of a therapeutic protein in a particular cell type, and more particularly, engineered cells for expression of a transgene to the brain of a patient. 本公开提供了通过插入人工外显子(ArtEx)对...