Lung respiration wafer and cell stretching culture platform and operation method thereof

• Main Authors: HE SHUJUAN, SONG JUNHUI, LAI PINCI, LIANG YIYING, LIU CHENGXIAN, HWANG SEUNG WOO, XU JIAMING, SUN WEILUN, LEE KANG-WON
• Format: Patent
• Language: Chinese; English
• Published: 17.02.2023
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; SPIRITS; VINEGAR; WINE

The invention discloses a pulmonary respiration wafer, a cell stretching culture platform and an operation method thereof. According to the pulmonary respiration wafer and cell stretching culture platform, motor output is controlled through programming, a microfluid wafer is stretched through a cam element, and the stretching frequency and the stretching amount are changed by changing the size of the cam element and the rotating frequency of a motor; the method comprises the following steps of: simulating lung breathing conditions in different states by using a liquid dielectrophoresis technology, performing three-dimensional arrangement on biocompatible hydrogel and cells in the hydrogel by using a liquid dielectrophoresis technology so as to imitate three-dimensional cell tissues, and perfusing drugs by using a dynamic perfusion system so as to realize a drug test platform when the cells in the wafer bionic lung tissues are stretched. 本发明公开一种肺呼吸晶片与细胞拉伸培养平台及其运作方法。肺呼吸晶片与细胞拉伸培养平台是通过程序编写控制马达输出、利用凸轮元件对微流体晶片进行拉伸、