7-or 8-hydroxy-isoquinoline and 7-or 8-hydroxy-quinoline derivatives as alpha-1 antitrypsin modulators for treatment of alpha-1 antitrypsin deficiency (AATD)

• Main Authors: BRODNEY MICHAEL AARON, TAPLEY, THOMAS, L, THOMSON STEPHEN ANDREW, SWEET, RAYMOND, J, COTTRELL KEVIN MICHAEL, DENINNO MICHAEL PAUL, STOW, STEPHEN, D, FANNING, LEV, T.D, DAMANIEZ, VINCENT, HURLEY, DENNIS, JAMES, MAXWELL, JOHN, P, SENTER, TIMOTHY, J, TANG, QING, GARER-DAI ZSOLT, HALL ANDREW BRIAN, GU WEI, JONES PHILIP, BOUCHER DAVID MICHAEL, CLARK MICHAEL P, JOHNSON, MICHAEL, A., JR, GIROUX SIMON
• Format: Patent
• Language: Chinese; English
• Published: 03.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed herein are 7-or 8-hydroxy-isoquinoline and 7-or 8-hydroxy-quinoline derivatives that are alpha-1 antitrypsin modulators for use in the treatment of alpha-1 antitrypsin deficiency (AATD). 本文公开了作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1抗胰蛋白酶调节剂的7-或8-羟基-异喹啉和7-或8-羟基-喹啉衍生物。