Carbon quantum dot and method for quantitatively detecting tumor vascular inhibitor DX1002 by using same

• Main Authors: LIU SHUYAO, XU XIAOPING, FU XIAOYUN, YONG ZHIQUAN
• Format: Patent
• Language: Chinese; English
• Published: 03.02.2023
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention provides a carbon quantum dot. The carbon quantum dot is prepared from the following raw materials: o-phenylenediamine, tryptophan and ferric salt, the carbon dots are stable in fluorescence, have excellent optical characteristics of resistance to biological background quenching and the like and have the characteristic of being quantitatively quenched by DX1002 specificity, a method for quantitatively detecting DX1002 is constructed by taking the carbon dots as a fluorescence probe, and the method can omit tedious sample pretreatment and interferent separation, is a rapid, sensitive, economical and high-throughput DX1002 analysis method, and can be widely applied to detection of DX1002. The method is suitable for in-vivo pharmacokinetic monitoring of DX1002, further analysis and research of anticancer candidate drug DX1002 are promoted, a new method and thought are provided for high-throughput detection application of carbon quantum dots in biological samples, and the rapid detection requirement