Preparation method and application of 3, 3-dialkoxy propyl methyl phosphonate
The invention discloses a preparation method and application of a glufosinate-ammonium key intermediate 3, 3-dialkoxy propyl methyl phosphonate. The preparation method comprises the following steps: by taking dimethoxyphosphorus chloride as a raw material, reacting with a Grignard reagent (prepared...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
03.01.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention discloses a preparation method and application of a glufosinate-ammonium key intermediate 3, 3-dialkoxy propyl methyl phosphonate. The preparation method comprises the following steps: by taking dimethoxyphosphorus chloride as a raw material, reacting with a Grignard reagent (prepared by reacting 3-halogenated-2, 2-dimethoxypropane with magnesium) or a Turbo Grignard reagent (prepared by reacting 3-halogenated-2, 2-dimethoxypropane with magnesium and an auxiliary agent lithium chloride) (also called as a Konchel Grignard reagent), and then carrying out an Arbuzov rearrangement reaction under the action of a catalyst to obtain the 3, 4-dimethoxyphosphorus chloride. The catalyst is 2, 3-dialkoxy propyl methyl methylphosphonate. Reaction raw materials used in the synthesis method are simple and easy to obtain, reaction conditions are easy to control, by-products generated in the reaction are few, the reaction yield is high, few three wastes are generated, the method is green and environmentally fri |
---|---|
Bibliography: | Application Number: CN202211278376 |