Preparation method and application of 3, 3-dialkoxy propyl methyl phosphonate

• Main Authors: JANG DAE YOUNG, LIU YING, ZHANG MENGHAN
• Format: Patent
• Language: Chinese; English
• Published: 03.01.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method and application of a glufosinate-ammonium key intermediate 3, 3-dialkoxy propyl methyl phosphonate. The preparation method comprises the following steps: by taking dimethoxyphosphorus chloride as a raw material, reacting with a Grignard reagent (prepared by reacting 3-halogenated-2, 2-dimethoxypropane with magnesium) or a Turbo Grignard reagent (prepared by reacting 3-halogenated-2, 2-dimethoxypropane with magnesium and an auxiliary agent lithium chloride) (also called as a Konchel Grignard reagent), and then carrying out an Arbuzov rearrangement reaction under the action of a catalyst to obtain the 3, 4-dimethoxyphosphorus chloride. The catalyst is 2, 3-dialkoxy propyl methyl methylphosphonate. Reaction raw materials used in the synthesis method are simple and easy to obtain, reaction conditions are easy to control, by-products generated in the reaction are few, the reaction yield is high, few three wastes are generated, the method is green and environmentally fri