GPC3 CAR-T cells secreting IL-18 and methods of making and using same

• Main Authors: JUNG JI-WON, CHOI JIN-KYUNG, KIM KWANGHEE, LEE SEUNG-HYUN, ZHANG RONGJUN, LEE HYE-MI, LI BAOLIN, KWON BYOUNG SE, LEE JEONG-YOON, SON HYUN-TAE, IM SUN-WOO
• Format: Patent
• Language: Chinese; English
• Published: 09.12.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided herein are CAR-T compositions directed against GPC3, including chimeric receptors, and engineered immune cells directed against GPC3. The disclosure also provides vectors, compositions, and methods of treatment using the GPC3 antigen binding molecules and engineered immune cells, optionally in combination with expression of IL-18. The GPC3CAR compositions provided herein can be used to treat some cancers. 本文提供了针对GPC3的CAR-T组合物，包括嵌合受体，以及针对GPC3的经工程改造的免疫细胞。本公开还提供载体、组合物，以及使用GPC3抗原结合分子和经工程改造的免疫细胞，任选地与IL-18的表达组合进行治疗的方法。本文提供的GPC3CAR组合物可以用于治疗一些癌症。