Deuteration method of methyl sulfide compound

• Main Authors: LIU FENG, BAO CANCAN, DU HUIZHEN, GUAN BINGTAO, SHI ZHANGJIE, LUO YANLONG
• Format: Patent
• Language: Chinese; English
• Published: 21.10.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention provides a deuteration method of a methyl sulfide compound, and belongs to the technical field of organic synthesis. Comprising the following steps: in an inert atmosphere, taking alkali metal salt as a catalyst, taking a methyl sulfide compound which is in a liquid state at a reaction temperature as a reactant, filling deuterium into a reaction container, and carrying out a closed reaction for a certain time at the reaction temperature to obtain the methyl sulfide deuterated compound, or taking the methyl sulfide compound as a reactant, adding a solvent, and carrying out a closed reaction for a certain time at the reaction temperature to obtain the methyl sulfide deuterated compound. The reaction general formula is as shown in the formula 1, and R1 and R2 are independently selected from any one of H, alkyl, aryl, substituted aryl, silyl, alkoxy or nitrogen alkyl, or R1 and R2 are bonded to form an aliphatic hydrocarbon ring or an aromatic ring. The deuteration method provided by the invention h