Pegylated lipid, liposome modified by pegylated lipid, pharmaceutical composition containing liposome, and preparation and application of pharmaceutical composition
The invention discloses a pegylated lipid and a preparation method thereof, a liposome containing the pegylated lipid, a pharmaceutical composition containing the liposome as well as a preparation and application of the pharmaceutical composition, and belongs to the field of drug delivery. The pegyl...
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Format | Patent |
Language | Chinese English |
Published |
18.10.2022
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Abstract | The invention discloses a pegylated lipid and a preparation method thereof, a liposome containing the pegylated lipid, a pharmaceutical composition containing the liposome as well as a preparation and application of the pharmaceutical composition, and belongs to the field of drug delivery. The pegylated lipid provided by the invention can be used for modifying the liposome, and can also be further modified and coupled with the targeting group and then used for modifying the liposome to obtain the liposome with the targeting group. Due to the existence of the long-chain PEG and the targeting group on the pegylated lipid, the modified liposome not only can effectively avoid the removal of the liposome by the reticuloendothelial system in the human body, but also can realize the targeting function. Therefore, when the pegylated lipid modified lipidosome delivers active drugs to cells or patients, especially nucleic acid drugs and anti-tumor drugs, the lipidosome not only can realize long circulation and improve |
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AbstractList | The invention discloses a pegylated lipid and a preparation method thereof, a liposome containing the pegylated lipid, a pharmaceutical composition containing the liposome as well as a preparation and application of the pharmaceutical composition, and belongs to the field of drug delivery. The pegylated lipid provided by the invention can be used for modifying the liposome, and can also be further modified and coupled with the targeting group and then used for modifying the liposome to obtain the liposome with the targeting group. Due to the existence of the long-chain PEG and the targeting group on the pegylated lipid, the modified liposome not only can effectively avoid the removal of the liposome by the reticuloendothelial system in the human body, but also can realize the targeting function. Therefore, when the pegylated lipid modified lipidosome delivers active drugs to cells or patients, especially nucleic acid drugs and anti-tumor drugs, the lipidosome not only can realize long circulation and improve |
Author | LIU QIAOYAN ZHU QI LIN SHENG LIN MINGGUI LIU CHAO WANG AILAN WENG WENGUI LIN CONGMING |
Author_xml | – fullname: WANG AILAN – fullname: LIN MINGGUI – fullname: LIN CONGMING – fullname: ZHU QI – fullname: LIN SHENG – fullname: LIU QIAOYAN – fullname: WENG WENGUI – fullname: LIU CHAO |
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DocumentTitleAlternate | 一种聚乙二醇化脂质及其修饰的脂质体、含该脂质体的药物组合物及其制剂和应用 |
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Snippet | The invention discloses a pegylated lipid and a preparation method thereof, a liposome containing the pegylated lipid, a pharmaceutical composition containing... |
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Title | Pegylated lipid, liposome modified by pegylated lipid, pharmaceutical composition containing liposome, and preparation and application of pharmaceutical composition |
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