Anti-T cell nano antibody and nucleic acid coding sequence and application thereof

• Main Authors: HUANG SHIWEI, CHEN MEIZHI, QIU SHAOZHI, LIN YUQUAN, PAN ZHIMING, CHEN YE, ZHOU DEYANG
• Format: Patent
• Language: Chinese; English
• Published: 30.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention provides an anti-T cell nano antibody which is specifically combined with CD3 epsilon. The invention also provides a nucleic acid coding sequence of the anti-T cell nano antibody, use of the anti-T cell nano antibody for treating cancer, immunomodulating and activating immune cells, and a method for detecting CD3 epsilon expression. 本发明提供一种抗-T细胞奈米抗体，其与一CD3ε专一性结合。本发明亦提供该抗-T细胞奈米抗体的核酸编码序列、该抗-T细胞奈米抗体用于治疗癌症、免疫调节及活化免疫细胞的用途，及用于检测CD3ε表现量的方法。