Application of traditional Chinese medicine composition in preparation of anti-syncytial virus medicine

• Main Authors: FU WAN, YANG ZIFENG, HE DI, WU BAIJIAN, WU CUIYUN, CHEN WEIPING, HUANG XIAODAN, XIE JUN, PENG SHAOZHONG, XU FAN, LUO YANYU, ZHENG RONGBO, DAI JUN, FANG GUANGHONG, HUANG JICHENG, MA QINHAI
• Format: Patent
• Language: Chinese; English
• Published: 20.09.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to application of a traditional Chinese medicine composition in preparation of an anti-syncytial virus medicine. The traditional Chinese medicine composition is prepared from honeysuckle flowers, radix scutellariae, herba schizonepetae, fructus gardeniae, fructus forsythiae, radix scrophulariae, bombyx batryticatus, radix rehmanniae, rhizoma belamcandae, radix platycodonis, herba menthae, periostracum cicadae, radix saposhnikoviae and radix glycyrrhizae. Experimental results show that the traditional Chinese medicine composition disclosed by the invention has an inhibiting effect on cytopathy caused by infection of Hep-2 cells by respiratory syncytial viruses (RSV) in vitro; the compound can inhibit the mRNA overexpression of inflammatory factors IL-6, IL-8 and TNF-alpha induced by a respiratory syncytial virus (RSV) in vitro, and has a dose-dependent relationship. 本申请涉及一种中药组合物在制备抗合胞病毒药物中的应用。其中，本申请的中药组合物由金银花、黄芩、荆芥、栀子、连翘、玄参、僵蚕、地黄、射干、桔梗、薄荷、蝉蜕、防风、甘草组成。实验结果表明，本申请的中药组合物在体外对呼吸道合胞病毒(RSV)感染Hep-2