Human liver chimeric non-human animals with defective p450 oxidoreductase and methods of use thereof

• Main Authors: DIEGUEZ MARIA DE LAS MERCEDES BARBA, BISSIG KLAUS-DIETER, PANKOVICH FRANCIS PATRICK
• Format: Patent
• Language: Chinese; English
• Published: 09.08.2022
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TRAPPING; VINEGAR; WINE

The present invention relates to human liver chimeric non-human animals with defective P450 oxidoreductase and methods of use thereof. The present disclosure provides chimeric non-human animals comprising human hepatocytes, methods for making chimeric non-human animals comprising human hepatocytes,...