Compound with TRK inhibitory activity, preparation method, composition and application thereof

• Main Authors: FAN FUTIAN, WANG XIAOJIAN, WU PENGFEI, SU XIAOTING, MA MINGYANG, DAI XINMIN, JIANG XINGKAI, WANG YAN
• Format: Patent
• Language: Chinese; English
• Published: 05.08.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of medicines, and particularly relates to a compound with TRK inhibitory activity, a preparation method, a composition and application of the compound. R1 and R2 independently represent hydrogen, fluorine, chlorine, bromine, iodine, an unsubstituted C1-4 alkyl group, a substituted C1-4 alkyl group, an unsubstituted C1-4 alkoxy group, a substituted C1-4 alkoxy group, an unsubstituted C1-4 alkylthio group, a substituted C1-4 alkylthio group, an unsubstituted C1-4 alkylamino group or a substituted C1-4 alkylamino group; m represents carbon, nitrogen, oxygen or sulfur; q1, Q2 and Q3 each independently represent carbon or nitrogen; w1 represents carbon or nitrogen; r3 and R4 independently represent hydrogen, fluorine, chlorine, bromine, iodine, aldehyde group, carboxyl group, hydroxyl group, amino group, sulfydryl group, unsubstituted C1-4 alkyl group, substituted C1-4 alkyl group, or the compound provided by the invention has good TRK inhibitory activity. 本发明属于药物领域，具体涉及具有TRK抑制活性