Biliary atresia potential molecular subtype and recognition method of core gene of biliary atresia potential molecular subtype

• Main Authors: LI HONGDONG, HONG GUINI, CHEN ZHIHONG
• Format: Patent
• Language: Chinese; English
• Published: 22.07.2022
• Subjects: CALCULATING; COMPUTING; COUNTING; HANDLING RECORD CARRIERS; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS; PRESENTATION OF DATA; RECOGNITION OF DATA; RECORD CARRIERS

The invention relates to a biliary atresia potential molecular subtype and core gene identification method, which comprises the following steps: based on a relative expression rank relationship among genes in a sample, mining potential gene pairs with subtype identification capability, and identifying and verifying the molecular subtype through clustering analysis. And then analyzing and identifying gene modules related to BA subtypes by using a weighted gene co-expression network, and screening core genes related to the subtypes. The biliary tract atresia subtype key gene identification method gets rid of limitation of gene expression absolute values, overcomes the disadvantage that expression values among different laboratories are incomparable, eliminates the influence of group difference on results to the greatest extent, and can be applied to single individual samples by the biliary tract atresia subtype key genes identified by the biliary tract atresia subtype key gene identification method. 本申请涉及一种胆道闭锁