Industrial preparation method of docusate calcium

• Main Authors: DAI XUYONG, WANG XIAOLI, LI SHAOKUI, WANG ZHIHUA, CHEN LIANG, QUAN WEI, WANG CHENG, CHENG ZHIGANG, LIU HAO, LU ZHENG
• Format: Patent
• Language: Chinese; English
• Published: 12.07.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to an industrial preparation method of docusate calcium. According to the preparation method, maleic anhydride and 2-ethyl hexanol are used as starting raw materials, p-toluenesulfonic acid is used for catalyzing to form ester, then the ester and sodium hydrogen sulfite are sulfonated in an alcohol-water solution, then calcium salt is prepared through one-pot boiling, a docusate calcium crude product is obtained, and finally pure water is used for refining to obtain a docusate calcium finished product. According to the method, the problem of residues of 2-ethylhexanol and sodium hydrogen sulfite is solved, the refining yield of docusate calcium reaches 95%, and the method is short in overall process route, high in yield, reliable in quality, low in cost, suitable for industrial production and extremely high in application value. 本发明属于医药化工技术领域，具体通过了一种多库酯钙的工业制备方法。该制备方法中以顺丁烯二酸酐和2-乙基己醇为起始原料，利用对甲苯磺酸催化成酯，再与亚硫酸氢钠在醇水溶液中