Sequential-release double-drug-loading hydrogel as well as preparation method and application thereof

• Main Authors: WEN JING, LI KEBI, ZHU CHENYUE, XU PEIHU, HUANG ZHIJUN, LI YUNHUI, LIN SIHUI, CHENG WANTING, XU JINGYI, XU HAIXING, WANG ZIYI, LYU LU, WANG SINING
• Format: Patent
• Language: Chinese; English
• Published: 24.06.2022
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention discloses sequential release double-drug-loading hydrogel, which is prepared by taking PBAE as a carrier material, loading vancomycin and forming the hydrogel with rhizoma drynariae general flavone nano-microspheres, and the material realizes sequential release of vancomycin and rhizoma drynariae general flavone, and has the advantages that the time sequence release of vancomycin and rhizoma drynariae general flavone is realized; and the two can play a synergistic effect to better promote the generation of osteoblasts, thereby having an application prospect in bone repair treatment. 本发明公开了一种时序释放双载药水凝胶，该水凝胶以PBAE为载体材料，通过负载万古霉素并与骨碎补总黄酮纳米微球形成水凝胶，从而制备双载药骨修复材料，该材料实现了万古霉素和骨碎补总黄酮的时序释放，使二者能发挥协同作用更好地促进成骨细胞生成，从而在骨修复治疗中具有应用前景。