Aptamer-based multispecific therapeutic agents

• Main Authors: BAUCH CECILE, RIC, MIODEK, ANNA, MORAN, FR, D
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides an engineered multispecific antigen binding molecule comprising two or more different aptamer moieties linked by a linker. The antigen binding molecules are capable of specifically binding to one or more antigens and bridging different types of cells, such as immune cells and cancer cells. The linked aptamers can be used to modulate and enhance immune function. 本发明提供一种工程化的多特异性抗原结合分子，其包括由连接体连接的两个或更多个不同适配体部分。抗原结合分子能够特异性结合到一个或多个抗原，并桥接不同类型的细胞，例如免疫细胞和癌细胞。连接的适配体可用于调节和增强免疫功能。