Gas phase coating for drug solubility control

• Main Author: NEIKIRK COLIN C
• Format: Patent
• Language: Chinese; English
• Published: 29.04.2022
• Subjects: APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL; SPRAYING OR ATOMISING IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

A method of preparing a pharmaceutical composition having a drug-containing core surrounded by one or more metal oxide materials is provided. The process comprises the sequential steps of (a) loading particles comprising a drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump purge cycles of the reactor using an inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump purge cycles of the reactor using an inert gas. The temperature of the particles does not exceed 35 DEG C. This results in a pharmaceutical composition comprising a drug-containing core surrounded by one or more metal oxide materials. 提供了一种制备药物组合物的方法，所述药物组合物具有由一种或多种金属氧化物材料包围的含药核。所述方法包括以下顺序步骤：(a)将包含药物的颗粒装载到反应器中，(b)将蒸气态或气态金属前驱物施加到所述反应器中的所述颗粒，(c)使用惰性气体执行所述反应器的一个或多个泵净化循环，(d)将蒸气态或气态氧化剂施加到所述反应器中的所述颗粒，以及(e)使用惰性气体执行所述反应器的一个或多个泵净化循环。所述颗粒的温度不超过35℃。这产生了一种药物组合物，所述药物组合物包括由一种或多种金属氧化物材料包围的含药核。