Triazolopyridine compound as well as preparation method and application thereof

• Main Authors: LI GUANGLEI, SU YANJING, GUO KAI, ZHU XIZHEN, XING QINGFENG, LUO QINHONG, YE CHUNQIANG
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a triazolopyridine compound as well as a preparation method and application thereof. The triazolopyridine compound is a compound as shown in a general formula A or at least one of a meso-mer, a raceme, an enantiomer, a diastereoisomer, a tautomer, a prodrug and a medicinal salt of the compound. The compound can effectively inhibit kinase activity, especially has a good inhibition effect on protein tyrosine kinase activity, has a clinical application prospect, and can be used for preparing drugs for preventing and/or treating related diseases. 一种三唑并吡啶类化合物及其制备方法与用途，所述三唑并吡啶类化合物为通式A所示的化合物或其内消旋体、外消旋体、对映异构体、非对映异构体、互变异构体、前药、可药用盐中的至少一种。该化合物可有效抑制激酶活性，尤其对蛋白酪氨酸激酶活性具有良好的抑制作用，具有临床应用前景，可用于制备预防和/或治疗相关疾病的药物。