Triazolopyridine compound as well as preparation method and application thereof

The invention relates to a triazolopyridine compound as well as a preparation method and application thereof. The triazolopyridine compound is a compound as shown in a general formula A or at least one of a meso-mer, a raceme, an enantiomer, a diastereoisomer, a tautomer, a prodrug and a medicinal s...

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Bibliographic Details
Main Authors LI GUANGLEI, SU YANJING, GUO KAI, ZHU XIZHEN, XING QINGFENG, LUO QINHONG, YE CHUNQIANG
Format Patent
LanguageChinese
English
Published 26.04.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a triazolopyridine compound as well as a preparation method and application thereof. The triazolopyridine compound is a compound as shown in a general formula A or at least one of a meso-mer, a raceme, an enantiomer, a diastereoisomer, a tautomer, a prodrug and a medicinal salt of the compound. The compound can effectively inhibit kinase activity, especially has a good inhibition effect on protein tyrosine kinase activity, has a clinical application prospect, and can be used for preparing drugs for preventing and/or treating related diseases. 一种三唑并吡啶类化合物及其制备方法与用途，所述三唑并吡啶类化合物为通式A所示的化合物或其内消旋体、外消旋体、对映异构体、非对映异构体、互变异构体、前药、可药用盐中的至少一种。该化合物可有效抑制激酶活性，尤其对蛋白酪氨酸激酶活性具有良好的抑制作用，具有临床应用前景，可用于制备预防和/或治疗相关疾病的药物。
Bibliography:Application Number: CN202210061211