Multifunctional nanofiber scaffold for improving cell adhesion and preparation method thereof

• Main Author: ZHUGE XIN
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2022
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

The invention discloses a multifunctional nanofiber scaffold for improving cell adhesion. The multifunctional nanofiber scaffold comprises a polylactic acid-glycolic acid nanofiber scaffold, and a polyurethane/polyacrylamide/gelatin hydrogel layer, a polydopamine layer and a chitosan network layer which are sequentially deposited on the surface of the nanofiber scaffold. The invention also discloses a preparation method of the multifunctional nanofiber scaffold for improving cell adhesion. The scaffold prepared by the invention not only has good mechanical properties, but also can effectively improve adhesion and proliferation of cells. 本发明公开了一种改善细胞黏附的多功能纳米纤维支架，包括聚乳酸乙醇酸纳米纤维支架，依次沉积在纳米纤维支架表面的聚氨酯/聚丙烯酰胺/明胶水凝胶层、聚多巴胺层、壳聚糖网络层。本发明还公开了该改善细胞黏附的多功能纳米纤维支架的制备方法。本发明制得的支架不仅力学性能好，且可有效改善细胞的粘附和增殖。