KCNT1 inhibitors and methods of use

• Main Authors: MARTINEZ BOTELLA GABRIEL, KARLIG MOHAMED KARIM MOHAMED, REDDY KIRAN, MULLEN BRIAN EDWARD, GRIFFIN ANDREW MARTIN, CHARIFSON PAUL S
• Format: Patent
• Language: Chinese; English
• Published: 01.04.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates, in part, to compounds and compositions useful in the prevention and/or treatment of neurological diseases or disorders, diseases or conditions associated with excessive neuronal excitability and/or acquired functional mutations in genes (e.g., KCNT1). Also provided herein are methods of treating neurological diseases or disorders, diseases or conditions associated with acquired functional mutations in excessive neuronal excitability and/or genes (e.g., KCNT1). 本发明部分涉及可用于预防和/或治疗神经疾病或病症、与过度神经元兴奋性和/或基因(例如，KCNT1)中的功能获得性突变相关的疾病或病状的化合物和组合物。本文还提供了治疗神经疾病或病症、与过度神经元兴奋性和/或基因(例如，KCNT1)中的功能获得性突变相关的疾病或病状的方法。