Application of hirsutine in medicine for treating thrombocytopenia

• Main Authors: YE YUN, LIN JING, WU JIANMING, YANG JING, KANG YAQI, WU ANGUO, WANG LONG
• Format: Patent
• Language: Chinese; English
• Published: 08.03.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of medicinal chemistry, in particular to application of hirsutine in preparation of a medicine for treating thrombocytopenia. The hirsutine is shown as a formula I in the specification. According to the application of hirsutine in preparing the medicine, the platelet level in the body can be remarkably improved, the bleeding risk of a patient with thrombocytopenia and the probability that blood needs to be transfused are reduced, and the blood transfusion infection risk is reduced; and compared with the limitation of high treatment cost of TPO and TPO receptor agonists (such as eltrombopag and romiscine), the hirsutine has the advantages of easiness in acquisition, lower cost, small side effect and the like, and can greatly reduce the family burden of patients and reduce the social medical security expenditure pressure. 本发明涉及药物化学领域，具体涉及毛钩藤碱在制备治疗血小板减少症药物中的应用；所述毛钩藤碱如式I所示。本发明毛钩藤碱在制备药物中的应用，可以显著提升体内血小板水平，降低血小板减少症患者的出血风险和需要输血的机率，降低输血感染风险；并且相比于TPO及TPO受体激动剂（如艾曲波帕、罗米司亭等）治疗费昂贵的限制，毛钩藤碱