BIOMIMETIC TISSUE-ADHESIVE HYDROGEL PATCH AND USE THEREOF

• Main Authors: CHO SEUNG-WOO, CHOI SOO JEONG, CHOI DONG-HOON, SHIN JI SOO
• Format: Patent
• Language: Chinese; English
• Published: 18.02.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to a biocompatible polymeric hydrogel patch which is modified with a catechol group or pyrogallol group and has excellent biocompatibility and tissue adhesion, and use thereof for drug delivery, cell transplantation, and tissue regeneration. The biocompatible polymeric hydrogel patch modified with a catechol group or a pyrogallol group has remarkably excellent mechanical properties and tissue adhesion, as compared to solution-based bulk hydrogels, and thus can carry cells and a drug in vivo for a long period of time and safely and efficiently deliver same to a target site. 本发明涉及一种邻苯二酚基或邻苯三酚基修饰的生物相容性及组织粘合力优秀的生物相容性聚合物水凝胶贴片以及利用其的药物递送、细胞移植和组织再生用途。上述邻苯二酚基或邻苯三酚基修饰的生物相容性聚合物水凝胶贴片相比基于溶液的本体水凝胶，具有显著优秀的机械性质及组织粘合力，因此可以在体内长时间装载细胞和药物，并安全有效地将上述细胞和药物递送到靶部位。