Macrocyclic compound as well as preparation method and application thereof

• Main Authors: LI GONG, LAN WENLI, XUE BAOYU, ZHANG PEILONG
• Format: Patent
• Language: Chinese; English
• Published: 18.02.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a macrocyclic compound as well as a preparation method and application thereof, the macrocyclic compound has a structure as shown in a formula I, and A, B, D, R1, R2, R3, R4, R5, Z, X, m, n and p are defined in the specification. The macrocyclic compound disclosed by the invention not only can overcome EGFR C797S mutation, but also can overcome EGFR T790M mutation, and is relatively high in selectivity. 本申请涉及大环化合物及其制备方法和应用，所述大环化合物具有下式I所示的结构：其中，A、B、D、R1、R2、R3、R4、R5、Z、X、m、n、p如说明书所定义。本申请的大环化合物既能克服EGFR C797S突变，又能克服EGFR T790M突变，而且选择性较高。