Preparation method of chlorpheniramine maleate impurity

The invention provides a preparation method of a chlorpheniramine maleate impurity, and belongs to the technical field of preparation of drug impurity standard substances. The method comprises the following steps: dissolving a compound shown in a formula 1 in a first solvent, conducting reacting wit...

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Bibliographic Details
Main Authors PENG JIN'AN, HE DONGMEI, LI FANGLIN
Format Patent
LanguageChinese
English
Published 21.01.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a preparation method of a chlorpheniramine maleate impurity, and belongs to the technical field of preparation of drug impurity standard substances. The method comprises the following steps: dissolving a compound shown in a formula 1 in a first solvent, conducting reacting with a first alkali for 30 minutes at a first temperature, and then conducting reacting with a compound shown in a formula 2 to obtain a compound shown in a formula 3; 2, reacting the compound shown in the formula 3 with second alkali in a second solvent at a second temperature to obtain a compound shown in a formula 4; and 3, reacting the compound shown in the formula 4 with a third alkali in a third solvent at a third temperature for 30 minutes, and conducting reacting with a compound shown in a formula 5 to obtain the chlorpheniramine maleate impurity. The method for preparing the chlorpheniramine maleate impurity has the advantages of simplicity in operation, short preparation period, few byproducts, easiness in p
Bibliography:Application Number: CN202111152628