BLOOD TREATMENT DEVICE COMPRISING ALKALINE PHOSPHATASE

• Main Authors: LITZINGER ISABELLE, PHILLIP KUEHN, SWARTJES JAN, REMPFER MARTIN, VOTTELER STEFANIE, STORR MARKUS
• Format: Patent
• Language: Chinese; English
• Published: 22.10.2021
• Subjects: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; TRANSPORTING

The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI). 本发明涉及一种血液处理装置，其被配置成在体外血液回路中对有需要的患者的血液中的细胞外三磷酸腺苷(ATP)、二磷酸腺苷(ADP)、一磷酸腺苷(AMP)和/或脂多糖(LPS)进行去磷酸化，其中，所述装置包括其上固定有碱性磷酸酶(AP)的基质。本发明还涉及包括本发明的血液处理装置的体外血液回路和血液处理装置作为药物的用途或治疗感染、优选血液或全身感染如败血症的方法，和/或用于治疗败血症相关的急性肾损伤(AKI)。