TGF Beta INHIBITOR AND PRODRUGS

A compound of formula (I) with improved TGF Beta signaling pathway inhibitory activity, improved therapeutic efficacy and improved toxicity profile, as well as two prodrugs thereof are disclosed. Compositions comprising said TGF Beta signaling pathway inhibitor and prodrugs thereof are also disclose...

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Main Authors BYROM DANIEL, RIERA ESCALE ANTONI, TAURIELLO DANIELE, BATLLE GOMEZ EDUARD, MATARIN MORALES JOAN ANTONI
Format Patent
LanguageChinese
English
Published 03.09.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (I) with improved TGF Beta signaling pathway inhibitory activity, improved therapeutic efficacy and improved toxicity profile, as well as two prodrugs thereof are disclosed. Compositions comprising said TGF Beta signaling pathway inhibitor and prodrugs thereof are also disclosed. Additionally, present invention discloses said compound of formula (I) and prodrugs thereof for use in a method of treating diseases responsive to TGF Beta signaling pathway inhibition. 公开了一种具有改善的TGFβ信号传导途径抑制活性、改善的治疗功效和改善的毒性特性的式(I)的化合物及其两种前药。还公开了包含所述TGFβ信号传导途径抑制剂及其前药的组合物。另外，本发明公开了所述式(I)的化合物及其前药，其用于治疗响应于TGFβ信号传导途径抑制的疾病的方法。
Bibliography:Application Number: CN201980089907