Benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as preparation method and application thereof
The invention belongs to the technical field of pharmacy, particularly discloses a benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as a preparation method and application thereof, and particularly relates to a compound in a general formula (I) and pharmaceutical...
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Format | Patent |
Language | Chinese English |
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24.08.2021
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Abstract | The invention belongs to the technical field of pharmacy, particularly discloses a benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as a preparation method and application thereof, and particularly relates to a compound in a general formula (I) and pharmaceutically acceptable salts thereof, and the drug can be used for preventing and/or treating diseases related to TRPV1 and/or MOR activity, such as pain, inflammation, immune dysfunction, neurological and psychiatric disorders, respiratory diseases, urinary and reproductive disorders. the invention also relates to a preparation method of the compounds and a pharmaceutical preparation containing the compounds.
本发明属于制药技术领域,具体公开了一种苄基哌嗪脲类TRPV1拮抗和MOR激动双靶点药物及其制备方法和应用,尤其涉及通式(Ⅰ)中化合物及其药学上可接受的盐,该药物可以用于预防和/或治疗与TRPV1和/或MOR活性相关的疾病,如疼痛、炎症、免疫功能障碍、神经和精神病症、呼吸道疾病、泌尿和生殖病症;本发明还涉及该类化合物的制备方法及含有它们的药物制剂; |
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AbstractList | The invention belongs to the technical field of pharmacy, particularly discloses a benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as a preparation method and application thereof, and particularly relates to a compound in a general formula (I) and pharmaceutically acceptable salts thereof, and the drug can be used for preventing and/or treating diseases related to TRPV1 and/or MOR activity, such as pain, inflammation, immune dysfunction, neurological and psychiatric disorders, respiratory diseases, urinary and reproductive disorders. the invention also relates to a preparation method of the compounds and a pharmaceutical preparation containing the compounds.
本发明属于制药技术领域,具体公开了一种苄基哌嗪脲类TRPV1拮抗和MOR激动双靶点药物及其制备方法和应用,尤其涉及通式(Ⅰ)中化合物及其药学上可接受的盐,该药物可以用于预防和/或治疗与TRPV1和/或MOR活性相关的疾病,如疼痛、炎症、免疫功能障碍、神经和精神病症、呼吸道疾病、泌尿和生殖病症;本发明还涉及该类化合物的制备方法及含有它们的药物制剂; |
Author | QIAO ZHENRUI YAN LIN GAO MENGKANG CHEN YINGDA WANG YUSUI SONG DEPU WANG GUOHAO |
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Snippet | The invention belongs to the technical field of pharmacy, particularly discloses a benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target... |
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Title | Benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as preparation method and application thereof |
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