Benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as preparation method and application thereof

• Main Authors: GAO MENGKANG, CHEN YINGDA, SONG DEPU, QIAO ZHENRUI, WANG GUOHAO, YAN LIN, WANG YUSUI
• Format: Patent
• Language: Chinese; English
• Published: 24.08.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of pharmacy, particularly discloses a benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as a preparation method and application thereof, and particularly relates to a compound in a general formula (I) and pharmaceutically acceptable salts thereof, and the drug can be used for preventing and/or treating diseases related to TRPV1 and/or MOR activity, such as pain, inflammation, immune dysfunction, neurological and psychiatric disorders, respiratory diseases, urinary and reproductive disorders. the invention also relates to a preparation method of the compounds and a pharmaceutical preparation containing the compounds. 本发明属于制药技术领域，具体公开了一种苄基哌嗪脲类TRPV1拮抗和MOR激动双靶点药物及其制备方法和应用，尤其涉及通式(Ⅰ)中化合物及其药学上可接受的盐，该药物可以用于预防和/或治疗与TRPV1和/或MOR活性相关的疾病，如疼痛、炎症、免疫功能障碍、神经和精神病症、呼吸道疾病、泌尿和生殖病症；本发明还涉及该类化合物的制备方法及含有它们的药物制剂；