Polyion compound of hyaluronic acid-epsilon-polylysine hydrochloride, and preparation method and application of polyion compound

• Main Authors: ZHAO XINXIN, GAO JUSHAN, HU DATAO, WEN JINPENG, WANG KE
• Format: Patent
• Language: Chinese; English
• Published: 27.07.2021
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses a polyion compound of hyaluronic acid-epsilon-polylysine hydrochloride as well as a preparation method and application of the polyion compound, belonging to the field of medical biological materials. The polyion compound of hyaluronic acid-epsilon-polylysine hydrochloride disclosed by the invention has good mechanical properties and strong adhesive capacity, and can effectively prevent a dressing from falling off from a wound; the polyion compound has good self-healing capability, and can realize self-healing in a short time after the dressing is broken due to external force; the polyion compound has good antibacterial ability, and has a good inhibition effect on gram-positive bacteria and gram-negative bacteria; and the polyion compound has good cell compatibility, and the use of a cross-linking agent is avoided through electrostatic compounding. According to the preparation method, a physical blending method is adopted, and hyaluronic acid with negative charges and epsilon-polylysine