Berberine hydrochloride microemulsion, preparation method thereof and application of berberine hydrochloride microemulsion in antibacterial drugs

• Main Authors: JIAO WENXIAO, ZHEN WENNA, LIU FENG, HAN CONG, LIU JINPENG, YUAN LIXUE, DU YAMIN, FU MAORUN
• Format: Patent
• Language: Chinese; English
• Published: 27.07.2021
• Subjects: AGRICULTURE; ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CANDLES; CHEMISTRY; DETERGENT COMPOSITIONS; DETERGENTS; FATTY ACIDS THEREFROM; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; RECOVERY OF GLYCEROL; RESIN SOAPS; SOAP OR SOAP-MAKING; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING; USE OF SINGLE SUBSTANCES AS DETERGENTS

The invention relates to the field of berberine hydrochloride drug carriers, and particularly provides a berberine hydrochloride microemulsion, a preparation method thereof and application of the berberine hydrochloride microemulsion in antibacterial drugs. The berberine hydrochloride microemulsion carrier is prepared from RH 60, Span80, EG (Ethylene Glycol) and PSO (Particle Swarm Optimization). The preparation method comprises the following steps: weighing RH 60, Span 80 and EG according to mass, uniformly conducting stirring and mixing at a certain temperature to form a first mixture, accurately weighing the first mixture and PSO according to a certain weight ratio, placing the components in a container, and uniformly conducting stirring and mixing at a certain temperature to form a second mixture; and dropwise adding a water phase into the container, and uniformly conducting mixing to obtain a third mixture, namely a target sample. The microemulsion drug carrier and the berberine hydrochloride can achieve