METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING CALCIPHYLAXIS

• Main Authors: RUDEY JOHN M, TUMLIN JAMES A, DARKE PAUL L
• Format: Patent
• Language: Chinese; English
• Published: 11.06.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides methods and compositions for preventing or treating (e.g., slowing the progression of, arresting, and/or reversing) calciphylaxis in a subject in need thereof and, more particularly, the invention relates to methods of using menaquinone-7(MK-7) and/or menaquinol-7(MKH2-7) for preventing or treating calciphylaxis in a subject with one or more of the following: diabetes, chronic kidney disease, end stage renal failure, and COPD or a subject undergoing hemodialysis and/or receiving anticoagulant therapy and/or statin therapy. 本发明提供了用于预防或治疗(例如，减缓发展、抑制和/或逆转)对其有需要的受试者中的钙化防御的方法和组合物，并且更具体地，本发明涉及使用甲基萘醌-7(MK-7)和/或甲基萘酚-7(MKH2-7)来预防或治疗患有以下：糖尿病、慢性肾病、终末期肾衰竭和COPD中的一种或多种的受试者或正在经历血液透析和/或接受抗凝剂疗法和/或抑制素疗法的受试者中的钙化防御的方法。