Synthesis method of 5-nitrothiophene-2-formaldehyde

The invention relates to the technical field of chemistry, in particular to a synthesis method of 5-nitrothiophene-2-formaldehyde. The method comprises the steps of mixing 2-thiophenecarboxaldehyde and acetic anhydride, carrying out nucleophilic addition reaction to generate (acetyloxy) (2-thiophene...

Full description

Saved in:
Bibliographic Details
Main Authors QIN YINGYUE, LI QING, ZHU LINLIN, WANG CHUANHU, TAI YANFANG, ZHANG CHUANLI
Format Patent
LanguageChinese
English
Published 11.06.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The invention relates to the technical field of chemistry, in particular to a synthesis method of 5-nitrothiophene-2-formaldehyde. The method comprises the steps of mixing 2-thiophenecarboxaldehyde and acetic anhydride, carrying out nucleophilic addition reaction to generate (acetyloxy) (2-thiophene) methyl acetate, and adding a nitrating agent to carry out nitration reaction to prepare 5-nitrothiophene-2-yl methylene diacetate; and carrying out a hydrolysis reaction on the obtained 5-nitrothiophene-2-yl methylene diacetate in a solvent to prepare 5-nitrothiophene-2-formaldehyde. The method has the beneficial effects that (1) cheap and easily available raw materials are used, the process is simple, the production cost is low, and the method is suitable for industrial production; and (2) the total yield and the total purity of the product are high. 本发明涉及化学技术领域，具体涉及一种5-硝基噻吩-2-甲醛的合成方法，包括如下步骤：2-噻吩甲醛和醋酐混合，经亲核加成反应生成(乙酰基氧基)(2-噻吩)乙酸甲酯，加入硝化剂发生硝化反应，制备得到5-硝基噻吩-2-基亚甲基二乙酸酯；所得5-硝基噻吩-2-基亚甲基二乙酸酯在溶剂中进行水解反应，制备得到5-硝基噻吩-2-甲醛；本发明
Bibliography:Application Number: CN202110298893