IMPROVING CELL-FREE DNA QUALITY

• Main Authors: WANG SILANG, LU YUMING, JIANG PEIYONG, ZENG ZHUOHAO, ZHAO HUIJUN
• Format: Patent
• Language: Chinese; English
• Published: 01.06.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided is a method for improving the quality of cell-free DNA for analysis, and the method can repair intrastrand defects in cell-free DNA. The repair of the defects in cell-free DNA may then allow for these repaired cell-free DNA to be analyzed by techniques, including sequencing and targeted capture enrichment. 提供了一种用于改善游离DNA的质量以进行分析的方法，所述方法可以修复游离DNA中的链内缺陷。对游离DNA中的所述缺陷进行的修复然后可以使这些经过修复的游离DNA通过包含测序和靶向捕获富集的技术进行分析。