Compositions and methods for metal containing formulations capable of modulating immune response

• Main Authors: SUN XIAOQI, MOON JAMES J
• Format: Patent
• Language: Chinese; English
• Published: 16.04.2021
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure provides compositions and methods for stimulating the innate immune response in a subject with agents capable of stimulating an innate immune response in a subject upon administration to the subject (e.g., damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs)). In particular, the present invention is directed to compositions of DAMPs/PAMPs and metals ions, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings). 本公开提供了用于在给药于受试者后用能够刺激所述受试者中的固有免疫应答的试剂刺激所述受试者中的固有免疫应答的组合物以及方法(例如，损伤相关分子模式(DAMP)和病原体相关分子模式(PAMP))。特别地，本发明涉及DAMP/PAMP和金属离子的组合物，以及利用这样的纳米颗粒的系统和方法(例如，在诊断和/或治疗设置中)。