Preparation method of argatroban impurity G

• Main Authors: LIU ZHAOGUO, CHEN AIFU, SONG GENGSHEN
• Format: Patent
• Language: Chinese; English
• Published: 09.04.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; SPIRITS; VINEGAR; WINE

The invention belongs to the field of synthesis of medical compounds, and particularly relates to a preparation method of an argatroban impurity G. The preparation method comprises the step of hydrolyzing argatroban salt under the catalytic action of arginase and manganese ions to obtain argatroban impurity G salt. The argatroban impurity G with the purity of 98% or more is successfully prepared by the synthesis method disclosed by the invention, and the route is reasonable, the operation method is simple and feasible, the yield is high, and the purity is high. 本发明属于医药化合物的合成领域，具体涉及一种阿加曲班杂质G的制备方法，包括阿加曲班盐在精氨酸酶和锰离子的催化作用下进行水解得到阿加曲班杂质G盐的步骤。本发明所述合成方法成功制备得到了纯度＞98％的阿加曲班杂质G，且路线合理，操作方法简单易行，收率高，纯度高。