MACROCYCLIZATION OF PEPTIDOMIMETICS

• Main Author: SHIPMAN MICHAEL
• Format: Patent
• Language: Chinese; English
• Published: 25.12.2020
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The invention provides an improved method of macrocyclization of peptidomimetics, as measured by isolated yields and product distribution, which comprises substitution of one or more of the backbone amide C=O bonds with a turn-inducing motif. The method is general with enhancements seen across a ran...