1,2,4-OXADIAZOLE COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICINAL USE THEREOF

• Main Authors: YIN HUIJUN, SHI JIANXIN, ZONG LIBIN, SI CHUNFENG, LIU CHUNYAN, YAN XU, MI ZHEN, WANG BIN
• Format: Patent
• Language: Chinese; English
• Published: 30.10.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to 1,2,4-oxadiazole compounds, a preparation method therefor and a use thereof, and in particular, to a compound represented by a general formula (I), a preparation method therefor, a pharmaceutical composition comprising the compound, and a use of the compound as a Farnesoid X receptor (FXR) agonist. The compound and the pharmaceutical composition comprising the compound can be used for treating and/or preventing diseases related to the activity of the FXR such as cholestasis, diabetes and complications thereof, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), obesity or metabolic syndrome (dyslipidemia, diabetes, and complications having an abnormally high body mass index), and cardiovascular disease. The definition of each substituent in the general formula (I) is the same as that in the description. 涉及1,2,4-噁二唑类化合物及其制备方法和医药用途，特别涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物，及其作为法尼醇衍生物X受体(Farnesoid X receptor，FXR)激动剂的用途，该化合物及含有该化合物的药物组合物可以用于治疗和/或预防与FXR活性相关的疾病