Application of mycoplasma bovis secretory protein MbovP570

• Main Authors: CHEN JIANGUO, CHEN YINGYU, HU CHANGMIN, ZHAO GANG, IHSANULLAH HIRANI, GUO AIZHEN, CHEN XI
• Format: Patent
• Language: Chinese; English
• Published: 30.10.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention discloses application of mycoplasma bovis secretory protein MbovP570 in preparation of mycoplasma bovis diagnostic reagents, drugs or vaccines, and belongs to the technical field of animal infectious disease prevention and treatment. The mycoplasma bovis secretory protein MbovP570 has a sequence as shown in SEQ ID NO: 1. 2 is an amino acid sequence shown in the specification; test proves that the mycoplasma bovis secretory protein MbovP570 has antigenicity and can be used for detecting mycoplasma bovis. The protein can react with mycoplasma bovis positive serum instead of mycoplasma bovis negative serum, the protein can induce bovine macrophages to highly express IL-8 and IL-12, IL-8 can activate neutrophils, and IL-12 can activate NK cells and T cells. Therefore, it is believed that MbovP570 can activate a host immune system and has important potential in research and development of new drugs and vaccines. 本发明公开了牛支原体分泌蛋白MbovP570在制备牛支原体诊断试剂、药物或疫苗中的应用，属于动物传染病防治技术领域。所述牛支原体分泌蛋白MbovP570具有如SEQ ID NO: